Effectiveness of an oral cholera vaccine in Zanzibar: findings from a mass vaccination campaign and observational cohort study

by Ahmed M Khatib, Mohammad Ali, Lorenz von Seidlein et al.
The Lancet Infectious Diseases, Vol. 12, Issue 11, pp. 837-844, November 2012

8 pp. 567 kB:
http://download.thelancet.com/pdfs/journals/laninf/PIIS1473309912701962.pdf

Zanzibar, in east Africa, has been severely and repeatedly affected by cholera since 1978. The authors assessed the effectiveness of oral cholera vaccination in high-risk populations in the archipelago to estimate the indirect (herd) protection conferred by the vaccine and direct vaccine effectiveness. They conclude that the oral cholera vaccine offers both direct and indirect (herd) protection in a sub-Saharan African setting. Mass oral cholera immunisation campaigns have the potential to provide not only protection for vaccinated individuals but also for the unvaccinated members of the community and should be strongly considered for wider use.

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