Mitigating the threat of artemisinin resistance in Africa: improvement of drug-resistance surveillance and response systems

by Ambrose O Talisuna, Corine Karema, Bernhards Ogutu et al.
The Lancet Infectious Diseases, Vol. 12, Issue 11, pp. 888-896, November 2012

9 pp. 496 kB:
http://download.thelancet.com/pdfs/journals/laninf/PIIS1473309912702414.pdf

Artemisinin-resistant Plasmodium falciparum malaria has emerged in western Cambodia and has been detected in western Thailand. Artemisinin resistance is a major threat to global public health, with the most severe potential effects in sub-Saharan Africa. The authors propose strategies that should be adopted by malaria-endemic countries in Africa: resource mobilisation to reactivate regional surveillance networks, establishment of baseline parasite clearance profiles to serve as benchmarks to track emerging artemisinin resistance, improved data sharing to allow pooled analyses to identify rare events, modelling of risk factors for drug resistance, and development and validation of new approaches to monitor resistance.

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