Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study

by Karen L Kotloff, James P Nataro, William C Blackwelder et al.
The Lancet, Vol. 382, Issue 9888, pp. 209-222, 20 July 2013

14 pp. 480 kB:
http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673613608442.pdf

Diarrhoeal diseases cause illness and death among children younger than 5 years in low-income countries. The authors designed the Global Enteric Multicenter Study (GEMS) to identify the aetiology and population-based burden of paediatric diarrhoeal disease in sub-Saharan Africa and south Asia. They conclude that interventions targeting five pathogens can substantially reduce the burden of moderate-to-severe diarrhoea. New methods and accelerated implementation of existing interventions (rotavirus vaccine and zinc) are needed to prevent disease and improve outcomes.

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