Single dose primaquine for clearance of Plasmodium falciparum gametocytes in children with uncomplicated malaria in Uganda: a randomised, controlled, double-blind, dose-ranging trial

by Alice C Eziefula, Teun Bousema, Shunmay Yeung et al.
The Lancet Infectious Diseases, Vol. 14, Issue 2, pp. 130-139, February 2014

10 pp. 349 kB:
http://download.thelancet.com/pdfs/journals/laninf/PIIS1473309913702688.pdf

Primaquine is the only available drug that clears mature Plasmodium falciparum gametocytes in infected human hosts, thereby preventing transmission of malaria to mosquitoes. However, concerns about dose-dependent haemolysis in people with glucose-6-phosphate dehydrogenase (G6PD) deficiencies have limited its use. The authors assessed the dose-response association of single-dose primaquine for gametocyte clearance and for safety in P falciparum malaria.

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