Incidence of multidrug-resistant tuberculosis disease in children: systematic review and global estimates

by Helen E Jenkins, Arielle W Tolman, Courtney M Yuen et al.
The Lancet, Vol. 383, Issue 9928, pp. 1572-1579, 3 May 2014

8 pp. 475 kB:
http://download.thelancet.com/pdfs/journals/lancet/PIIS0140673614601951.pdf

Multidrug-resistant tuberculosis threatens to reverse recent reductions in global tuberculosis incidence. Although children younger than 15 years constitute more than 25% of the worldwide population, the global incidence of multidrug-resistant tuberculosis disease in children has never been quantified. The authors aimed to estimate the regional and global annual incidence of multidrug-resistant tuberculosis in children. They conclude that their estimates underscore that many cases of tuberculosis and multidrug-resistant tuberculosis disease are not being detected in children. Future estimates can be refined as more and better tuberculosis data and new diagnostic instruments become available.

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