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The study collection provides evidence that safe, high quality voluntary medical male circumcision (VMMC) services performed by trained healthcare professionals in low resource settings can be implemented and sustained at scale and has the potential to significantly prevent new HIV infections in adolescent and adult men. These research studies focus on five African countries. The papers summarize many of the lessons learned during the accelerated scale-up of VMMC as several countries have moved to high volume VMMC services. As the findings point out, providing VMMC services offers a unique opportunity to reach men as never before, and often for the first time in their lives, with critical sexual and reproductive health services and to link them with HIV care and treatment when necessary.