by Brian J Taylor, Anita Howell, Kimberly A Martin et al.
Malaria Journal 2014, 13:179 (9 May 2014)
This study describes the development of a Polymerase Chain Reaction (PCR) lab-on-chip from initial concept to ready-for-manufacture design. The technology has the potential to make major inroads by supporting key areas of malaria control: as a diagnostic for acute malaria, for surveillance in elimination settings, and as a tool in clinical evaluations of new drugs and vaccines. Furthermore, test chips can be adapted to detect other pathogens for a differential diagnosis in the field. The flexibility, reliability, and robustness of this technology hold much promise for its use as a novel molecular diagnostic platform in developing countries.