Estimates of possible severe bacterial infection in neonates in sub-Saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis

by Anna C Seale, Hannah Blencowe, Alexander A Manu et al.
Lancet Infect Dis 2014; Published Online June 26, 2014

10 pp. 648 kB:
http://download.thelancet.com/pdfs/journals/laninf/PIIS1473309914708047.pdfS1473309914X70714_cov150h

Bacterial infections are a leading cause of the 2.9 million annual neonatal deaths. Treatment is usually based on clinical diagnosis of possible severe bacterial infection (pSBI). To guide programme planning, the authors have undertaken the first estimates of neonatal pSBI, by sex and by region, for sub-Saharan Africa, south Asia, and Latin America. They conclude that the need-to-treat population for pSBI in these three regions is high, with ten cases of pSBI diagnosed for each associated neonatal death. Deaths and disability can be reduced through improved prevention, detection, and case management.

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