Cerebral malaria in children: using the retina to study the brain

by Ian J. C. MacCormick, Nicholas A. V. Beare, Terrie E. Taylor et al.
Brain 2014: 137; 2119-2142

24 pp. 845 kB:
http://m.brain.oxfordjournals.org/content/137/8/2119.full.pdf8.cover

Cerebral malaria is a dangerous complication of Plasmodium falciparum infection, which takes a devastating toll on children in sub-Saharan Africa. Although autopsy studies have improved understanding of cerebral malaria pathology in fatal cases, information about in vivo neurovascular pathogenesis is scarce because brain tissue is inaccessible in life. The authors critically appraise evidence for associations between retina and brain neurovasculature in health and disease, and in the process they develop new hypotheses about why these vascular beds are susceptible to sequestration of parasitized erythrocytes.

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