Loop-mediated isothermal amplification (LAMP) for point-of-care detection of asymptomatic low-density malaria parasite carriers in Zanzibar

by Jackie Cook, Berit Aydin Schmidt, Iveth J González et al.
Malaria Journal 2015, 14:43 (28 January 2015)

12 pp. 329 kB:

Asymptomatic, low parasite density malaria infections are difficult to detect with currently available point-of-care diagnostics. This study piloted a loop-mediated isothermal amplification (LAMP) kit for field-friendly, high-throughput detection of asymptomatic malaria infections during mass screening and treatment (MSAT) in Zanzibar, a malaria pre-elimination setting. Despite lower than expected prevalence, LAMP detected a higher number of infections than the currently used diagnostic, rapid diagnostic test (RDT). LAMP is a field-friendly, sensitive diagnostic test that could be useful for MSAT malaria campaigns which require quick results to enable prompt treatment.

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