Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study

by Wendelin Moser, Said M Ali, Shaali M Ame et al.
Lancet Infect Dis 2016; 16: 53–60 – Published Online: September 18, 2015

8 pp. 362 kB
http://thelancet.com/pdfs/journals/laninf/PIIS1473-3099(15)00271-6.pdfcov200h_resize

Commonly used drugs for preventive chemotherapy against soil-transmitted helminths (ie, albendazole and mebendazole) show low efficacy against Trichuris trichiura. Recent studies with oxantel pamoate revealed good cure rates and high egg-reduction rates against T trichiura. The authors’ dose-finding study revealed an excellent tolerability profile of oxantel pamoate in children infected with T trichiura. An optimum therapeutic dose range of 15–30 mg/kg oxantel pamoate was defined.

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