Updates on the risk factors for latent tuberculosis reactivation and their managements

by Jing-Wen Ai, Qiao-Ling Ruan, Qi-Hui Liu et al.
Emerging Microbes & Infections (2016) 5, – Published online 3 February 2016

8 pp. 379 kB

The preventive treatment of latent tuberculosis infection (LTBI) is of great importance for the elimination and control of tuberculosis (TB) worldwide, but existing screening methods for LTBI are still limited in predicting the onset of TB. Previous studies have found that some high-risk factors (including human immunodeficiency virus (HIV), organ transplantation, silicosis, tumor necrosis factor-alpha blockers, close contacts and kidney dialysis) contribute to a significantly increased TB reactivation rate. This article reviews each risk factor’s association with TB and approaches to address those factors.

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