Yellow Fever in Angola and Beyond – The Problem of Vaccine Supply and Demand

by Alan D.T. Barrett
N Engl J Med 2016; 375:301-303, July 28, 2016

3 pp. 474 kB 003

In December 2015, a yellow fever outbreak was identified in Angola. That outbreak continues, despite distribution of nearly 12 million doses of vaccine in the country, and as of May 20, 2016, a total of 2420 suspected cases, including 298 deaths, had been reported. Given that we have a highly effective yellow fever vaccine that confers lifelong immunity with one dose, why is yellow fever still a problem? Much of the answer comes down to vaccine supply and demand.

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