Antiretroviral Therapy for the Prevention of HIV-1 Transmission

by Myron S. Cohen, Ying Q. Chen, Marybeth McCauley et al.
N Engl J Med 2016; 375:830-839, September 1, 2016

10 pp. 326 kB 003

An interim analysis of data from the HIV Prevention Trials Network (HPTN) 052 trial showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. ART was then offered to all patients with HIV-1 infection. The study included more than 5 years of follow-up to assess the durability of such therapy for the prevention of HIV-1 transmission. The authors conclude that successful treatment of HIV-1 is a highly effective tool for the prevention of sexual transmission of the virus. These findings support the results of observational studies and controlled clinical trials showing the personal and public health benefits of the earliest possible initiation of HIV-1 treatment.

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