The Use of Loop-Mediated Isothermal Amplification (TB-LAMP) for the Diagnosis of Pulmonary Tuberculosis: Policy Guidance

by Christopher Gilpin, Alexei Korobitsyn, Karin Weyer et al.
World Health Organization, 2016

52 pp. 3.0 MB 006_resize

A commercial molecular assay Loopamp MTBC Detection Kit based on loop-mediated isothermal amplification was developed for the detection of Mycobacterium tuberculosis complex (TB-LAMP). TB-LAMP is a manual assay that requires less than one hour to perform and can be read with the naked eye under ultra violet light. Following review of the latest evidence, WHO recommends that TB-LAMP can be used as a replacement for microscopy for the diagnosis of pulmonary TB in adults with signs and symptoms of TB. It can also be considered as a follow-on test to microscopy in adults with signs and symptoms of pulmonary TB, especially when further testing of sputum smear-negative specimens is necessary.

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