by Matteo Zignol, Anna S. Dean, Dennis Falzon et al.
N Engl J Med 2016; 375:1081-1089, September 15, 2016
9 pp. 629 kB
In 1994, the Global Tuberculosis Program of the World Health Organization (WHO), with the support of the International Union against Tuberculosis and Lung Disease (the Union), established the Global Project on Anti-Tuberculosis Drug Resistance Surveillance to measure the magnitude of drug resistance and to monitor trends. This project remains the oldest and largest initiative on the surveillance of antimicrobial resistance in the world. In this article, the authors describe the history of global surveillance of drug resistance in tuberculosis and discuss methods for surveillance, the quality of available data, the key achievements and findings to date, the main challenges that remain, and future directions.