Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells

by Han Sang Park, Matthew T. Rinehart, Katelyn A. Walzer et al.
PLoS ONE 11(9): e0163045 – Published: September 16, 2016

19 pp. 3.0 MB
http://journals.plos.org/plosone/article/asset?id=10.1371/journal.pone.0163045.PDFlogo-plos-95

Malaria detection through microscopic examination of stained blood smears is a diagnostic challenge that heavily relies on the expertise of trained microscopists. This paper presents an automated analysis method for detection and staging of red blood cells infected by the malaria parasite Plasmodium falciparum at trophozoite or schizont stage. Overall, this methodology points to a significant clinical potential of using quantitative phase imaging to detect and stage malaria infection without staining or expert analysis.

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