Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

by Jie Liu, James A Platts-Mills, Jane Juma et al.
The Lancet Vol. 388, No. 10051, pp. 1291–1301, 24 September 2016

11 pp. 1.2 MB
http://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(16)31529-X.pdfcov200h

Diarrhoea is the second leading cause of mortality in children worldwide, but establishing the cause can be complicated by diverse diagnostic approaches and varying test characteristics. The authors conclude that a quantitative molecular diagnostic approach improved population-level and case-level characterisation of the causes of diarrhoea and indicated a high burden of disease associated with only six pathogens, for which targeted treatment should be prioritised.

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