Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention

by Mary G. Fowler, Min Qin, Susan A. Fiscus et al.
N Engl J Med 2016; 375:1726-1737, November 3, 2016

12 pp. 590 kB
http://www.nejm.org/doi/pdf/10.1056/NEJMoa1511691image-009

Randomized-trial data on the risks and benefits of antiretroviral therapy (ART) as compared with zidovudine and single-dose nevirapine to prevent transmission of the human immunodeficiency virus (HIV) in HIV-infected pregnant women with high CD4 counts are lacking. From this study the authors conclude that antenatal ART resulted in significantly lower rates of early HIV transmission than zidovudine alone but at a higher risk of adverse maternal and neonatal outcomes.

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