Primer on Tuberculosis

by Madhukar Pai, Marcel A. Behr, David Dowdy et al.
Nature Reviews, Disease Primers, Volume 2, 2016 – Published online 27 October 2016

The article can be freely downloaded for a 1-month period only.

23 pp. 3.6 MB
http://www.nature.com/articles/nrdp201676.pdf10099329315376912275_resize

TB continues to be a major cause of morbidity and mortality, and drug-resistant TB is a major concern in many settings. Although several new TB diagnostics have been developed, including rapid molecular tests, there is a need for simpler point-of-care tests. Treatment usually requires a prolonged course of multiple antimicrobials, stimulating efforts to develop shorter drug regimens. Although the Bacillus Calmette–Guérin (BCG) vaccine is used worldwide, mainly to prevent life-threatening TB in infants and young children, it has been ineffective in controlling the global TB epidemic. Thus, efforts are underway to develop newer vaccines with improved efficacy. New tools as well as improved programme implementation and financing are necessary to end the global TB epidemic by 2035.

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