Effectiveness of one dose of oral cholera vaccine in response to an outbreak: a case-cohort study

by Andrew S Azman, Lucy A Parker, John Rumunu et al.
The Lancet Global Health, Vol. 4, No. 11, e856–e863, November 2016

8 pp. 307 kB

Oral cholera vaccines represent a new effective tool to fight cholera and are licensed as two-dose regimens with 2-4 weeks between doses. Evidence from previous studies suggests that a single dose of oral cholera vaccine might provide substantial direct protection against cholera. During a cholera outbreak in May, 2015, in Juba, South Sudan, the Ministry of Health, Médecins Sans Frontières, and partners engaged in the first field deployment of a single dose of oral cholera vaccine to enhance the outbreak response. The authors did a vaccine effectiveness study in conjunction with this large public health intervention. They conclude that one dose of Shanchol was effective in preventing medically attended cholera in this study. These results support the use of a single-dose strategy in outbreaks in similar epidemiological settings.

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