Clinical Infectious Diseases, Vol. 63, Suppl. 4, December 1, 2016
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It is amazing that in the 21st century, more than 100 years since Jules Bordet discovered the organism that bears his name, Bordetella pertussis, we are far from a full understanding of the organism, the disease, the correlates of protection, and the ideal vaccine. Unlike many infectious diseases, natural infection does not give lifelong immunity, and unlike our best vaccines, immunity after vaccination is more or less transient. Therefore, it is not surprising that control of pertussis is relatively poor, although generalizations are difficult because of geographical differences.