Development of HIV drug resistance and therapeutic failure in children and adolescents in rural Tanzania: an emerging public health concern

by Lukas Muri, Anna Gamell, Alex J. Ntamatungiro et al.
AIDS: 2 January 2017 – Vol. 31 – Issue 1, xlargethumb-00002030-201609240-00000-cv pp. 61–70

10 pp. 441 kB

http://pdfs.journals.lww.com/aidsonline/2017/01020/Development_of_HIV_drug_resistance_and_therapeutic.7.pdf

All children 18 years or less attending the paediatric HIV Clinic of Ifakara and on antiretroviral therapy (ART) for at least 12 months were enrolled. Virologic failure rates in children and adolescents were high, with the majority of ART-failing children harbouring drug resistance-associated mutations (HIV-DRM). The WHO criteria for immunologic treatment failure yielded an unacceptably low sensitivity. Viral load monitoring is urgently needed to maintain future treatment options for the millions of African children living with HIV.

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