by Patrícia Brasil, José P. Pereira, Jr., M. Elisabeth Moreira et al.
N Engl J Med 2016; 375:2321-2334, December 15, 2016
14 pp. 458 kB
Zika virus (ZIKV) has been linked to central nervous system malformations in fetuses. To characterize the spectrum of ZIKV disease in pregnant women and infants, the authors followed patients in Rio de Janeiro to describe clinical manifestations in mothers and repercussions of acute ZIKV infection in infants. They conclude that despite mild clinical symptoms in the mother, ZIKV infection during pregnancy is deleterious to the fetus and is associated with fetal death, fetal growth restriction, and a spectrum of central nervous system abnormalities.