Novel pH sensing semiconductor for point-of-care detection of HIV-1 viremia

by R. Gurrala, Z. Lang, L. Shepherd et al.
Nature Scientific Reports 6, Article number: 36000, Published online: 10 November 2016

6 pp. 679 kB
http://www.nature.com/articles/srep36000.pdf

The timely detection of viremia in HIV-infected patients receiving antiviral treatment is key to ensuring effective therapy and preventing the emergence of drug resistance. In high HIV burden settings, the cost and complexity of diagnostics limit their availability. The authors have developed a novel complementary metal-oxide semiconductor (CMOS) chip based, pH-mediated, point-of-care HIV-1 viral load monitoring assay that simultaneously amplifies and detects HIV-1 RNA. Median time to detection was 20.8 minutes in samples with >1000 copies RNA. The sensitivity, specificity and reproducibility are close to that required to produce a point-of-care device which would be of benefit in resource poor regions, and could be performed on an USB stick or similar low power device.

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