Relationship between time to initiation of antiretroviral therapy and treatment outcomes: a cohort analysis of ART eligible adolescents in Zimbabwe

by Florian Vogt, Andrea Rehman, Katharina Kranzer et al.
JAIDS; Journal of Acquired Immune Deficiency Syndromes: Post Acceptance: December 15, 2016

29 pp. 1.7 MB

Age-specific retention challenges make ART initiation in adolescents difficult, often requiring a lengthy preparation process. This needs to be balanced against the benefits of starting treatment quickly. The optimal time to initiation duration in adolescents is currently unknown. The authors conclude that neither mortality or loss to follow-up (LTFU) was associated with varying time to ART. The initiation process can be tailored to the adolescents’ needs and individual life situations without risking to increase poor treatment outcomes. Early mortality was high despite rapid ART initiation, calling for earlier rather than faster initiation through HIV testing scale-up.

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