The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong Subregion: a molecular epidemiology observational study

by Mallika Imwong, Kanokon Suwannasin, Chanon Kunasol et al.
Lancet Infect Dis 2017 – Published Online February 1, 2017

7 pp. 539 kB
http://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(17)30048-8.pdf

The study results suggest that the dominant artemisinin-resistant P falciparum C580Y lineage probably arose in western Cambodia and then spread to Thailand and Laos, outcompeting other parasites and acquiring piperaquine resistance. The emergence and spread of fit artemisinin-resistant P falciparum parasite lineages, which then acquire partner drug resistance across the Greater Mekong subregion, threatens regional malaria control and elimination goals. Elimination of falciparum malaria from this region should be accelerated while available antimalarial drugs still remain effective.

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