Relationship between Time to Initiation of Antiretroviral Therapy and Treatment Outcomes: A Cohort Analysis of ART Eligible Adolescents in Zimbabwe

by Florian Vogt, Andrea M. Rehman, Katharina Kranzer et al.
JAIDS: Journal of Acquired Immune Deficiency Syndromes: 1 April 2017, Vol. 74. Issue 4. pp. 390–398

9 pp. 679 kB

Antiretroviral therapy (ART) scale-up has reduced HIV-related deaths substantially. Adolescents remain the only age group where HIV-associated mortality is still rising, mainly because of delayed diagnosis and high attrition, and in particular around the time of ART initiation. Currently, multiple preparatory counselling and education sessions stretching over several weeks are considered necessary before treatment start to ensure long-term retention and adherence. The authors investigated treatment initiation patterns and related patient outcomes, and in particular the effect of time to ART initiation on mortality and loss to follow-up (LTFU) among treatment eligible adolescents aged ≥10 to <19 years registered in a public sector HIV care service in Bulawayo, Zimbabwe.

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