Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease

by Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran et al.
PLoS Negl Trop Dis 11(2): e0005356 – Published: February 23, 2017

21 pp 5.5 MB

The non-specific symptoms of Ebola Virus Disease (EVD) pose a major problem to triage and isolation efforts at Ebola Treatment Centres (ETCs). Under the current triage protocol, half the patients allocated to high-risk “probable” wards were EVD(-): a misclassification speculated to predispose nosocomial EVD infection. This study proposes a highly predictive and easy-to-use triage tool, which stratifies the risk of EVD infection with 89% discriminative power for both EVD(-) and EVD(-)/malaria(+) differential diagnoses. Improved triage could preserve resources by identifying those in need of more specific differential diagnostics as well as bolster infection prevention/control measures by better compartmentalizing the risk of nosocomial infection.

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