The Mass Production of Redundant, Misleading, and Conflicted Systematic Reviews and Meta-analyses

by John P.A. Ioannidis
Milbank Q. 2016 Sep;94(3):485-514

30 pp. 264 kB
http://onlinelibrary.wiley.com/doi/10.1111/1468-0009.12210/epdf

Currently, most systematic reviews and meta-analyses are done retrospectively with fragmented published information. This article aims to explore the growth of published systematic reviews and meta-analyses and to estimate how often they are redundant, misleading, or serving conflicted interests. The author concludes that the production of systematic reviews and meta-analyses has reached epidemic proportions. Possibly, the large majority of produced systematic reviews and meta-analyses are unnecessary, misleading, and/or conflicted.

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