Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: a modelling study

by Michael A Irvine, Wilma A Stolk, Morgan E Smith et al.
The Lancet Infectious Diseases, Vol. 17, No. 4, pp. 451–458, April 2017

8 pp. 433 kB
http://www.thelancet.com/pdfs/journals/laninf/PIIS1473-3099(16)30467-4.pdf

Lymphatic filariasis is targeted for elimination as a public health problem by 2020. The principal approach used by current programmes is annual mass drug administration with two pairs of drugs with a good safety profile. However, one dose of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) has been shown to clear the transmissible stage of the helminth completely in treated individuals. Simulation modelling suggests that the triple-drug regimen has potential to accelerate the elimination of lymphatic filariasis if high population coverage of mass drug administration can be achieved and if systematic non-adherence with mass drug administration is low.

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