Treatment outcomes for multidrug-resistant tuberculosis under DOTS-Plus: a systematic review and meta-analysis of published studies

by Kelemu Tilahun Kibret, Yonatan Moges, Peter Memiah et al.
Infectious Diseases of Poverty, 2017 6:7 – Published: 17 January 2017

8 pp. 1.6 MB
https://idpjournal.biomedcentral.com/track/pdf/10.1186/s40249-016-0214-x?
site=idpjournal.biomedcentral.com

This study revealed that patients with multidrug-resistant tuberculosis (MDR-TB) exhibited a very low treatment success rate compared to the World Health Organization 2015 target of at least 75 to 90%. The high default rate observed by conducting this literature review could possibly explain the spread of the MDR-TB strain in various populations. A better treatment success rate was observed among patients in individualized treatment regimens than in standardized ones. Conducting further individual-based meta-analysis is recommended to identify potential factors for defaulting treatment using large-scale and multi-center studies.

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