Integrating Clinical Research into Epidemic Response: The Ebola Experience

by Gerald Keusch, Keith McAdam, Patricia Cuff et al.
National Academies of Sciences, Engineering, and Medicine, 2017

287 pp. 5.5 MB
https://download.nap.edu/cart/download.cgi?record_id=24739

The Ebola virus has been known since 1976, when two separate outbreaks were identified in the Democratic Republic of Congo (then Zaire) and South Sudan (then Sudan). However, because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Health Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak.

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