by Tiphaine Gaillard, Sébastien Briolant, Marylin Madamet et al.
Malaria Journal, 2017, 16:148 – Published: 13 April 2017
Anti-malarial drug resistance to chloroquine and sulfadoxine–pyrimethamine has spread from Southeast Asia to Africa. Furthermore, the recent emergence of resistance to artemisinin-based combination therapy (ACT) in Southeast Asia highlights the need to identify new anti-malarial drugs. Doxycycline is not used in young children under 8 years of age due to its contraindication due to the risk of yellow tooth discolouration and dental enamel hypoplasia. However, recent studies report little or no effects of doxycycline on tooth staining or dental enamel hypoplasia in children under 8 years of age. It is time to rehabilitate doxycycline and to recommend it for malaria treatment in children under 8 years of age.