Limitations of Rapid Diagnostic Testing in Patients with Suspected Malaria: A Diagnostic Accuracy Evaluation from Swaziland, a Low-Endemicity Country Aiming for Malaria Elimination

by Nikhil Ranadive, Simon Kunene, Sarah Darteh et al.
Clin Infect Dis (2017) 64 (9): 1221-1227 – Published: 27 March 2017

7 pp. 343 kB
https://academic.oup.com/cid/article-pdf/64/9/1221/13635200/cix131.pdf

In the low-transmission setting of Swaziland, the authors demonstrated low sensitivity of Rapid Diagnostic Tests (RDTs) for malaria diagnosis, owing to an unexpectedly high proportion of low-density infection among symptomatic subjects. The positive predictive value (PPV) was also low, requiring further investigation. A more accurate point-of-care diagnostic may be needed to support malaria elimination efforts.

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