by Manica Balasegaram, Peter Kolb, John McKew et al.
PLoS Med 14(4):e1002276 – 18 April 2017
This Essay outlines how open source methods of working could be applied to the discovery and development of new medicines. There are many potential advantages of an open source approach, such as improved efficiency, the quality and relevance of the research, and wider participation by the scientific and patient communities; a blend of traditional and innovative financing mechanisms will have to be adopted. To evaluate properly the effectiveness of an open source methodology and its potential as an alternative model of drug discovery and development, the authors recommend that new projects be trialled and existing projects scaled up.