Integrating Clinical Research into Epidemic Response: The Ebola Experience

Editors: Gerald Keusch, Keith McAdam, Patricia A. Cuff et al.
National Academies of Sciences, Engineering, and Medicine, 2017

342 pp. 2.5 MB

The 2014–2015 Ebola epidemic in western Africa was the longest and most deadly Ebola epidemic in history, resulting in 28,616 cases and 11,310 deaths in Guinea, Liberia, and Sierra Leone. Because all Ebola outbreaks prior to that in West Africa in 2014–2015 were relatively isolated and of short duration, little was known about how to best manage patients to improve survival, and there were no approved therapeutics or vaccines. When the World Health Organization declared the 2014-2015 epidemic a public health emergency of international concern in August 2014, several teams began conducting formal clinical trials in the Ebola affected countries during the outbreak.

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