Severity of Pneumonia in Under 5-Year-Old Children from Developing Countries: A Multicenter, Prospective, Observational Study

by Thomas Bénet, Valentina Sanchez Picot, Shally Awasthi et al.
The American Journal of Tropical Medicine and Hygiene, Vol. 97, Issue 1, July 2017, pp. 68 – 76

9 pp. 589 kB
http://www.ajtmh.org/deliver/fulltext/14761645/97/1/tpmd160733.pdf?
itemId=/content/journals/10.4269/ajtmh.16-
0733&mimeType=pdf&containerItemId=content/journals/14761645

Pneumonia is the leading cause of death in children. The objectives were to evaluate the microbiological agents linked with hypoxemia in hospitalized children with pneumonia from developing countries, to identify predictors of hypoxemia, and to characterize factors associated with in-hospital mortality. Detection of human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) in respiratory samples was independently associated with increased risk of hypoxemia. Lower chest indrawing and cyanosis were predictive of hypoxemia. Predictors of death were Streptococcus pneumoniae detection by blood PCR.

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