HIV misdiagnosis in sub-Saharan Africa: performance of diagnostic algorithms at six testing sites

by Cara S. Kosack, Leslie Shanks, Greet Beelaert et al.
Journal of the International AIDS Society 2017, 20:21419

18 pp. 645 kB

In this prospective multisite diagnostic evaluation study (Guinea, Uganda, Kenya, Cameroun and Democratic Republic of Congo), samples from clients testing for HIV were collected and compared to a state-of-the-art algorithm from the AIDS reference laboratory at the Institute of Tropical Medicine, Belgium. The authors conclude that the performance of algorithms at several sites failed to meet expectations and thresholds set by the World Health Organization, with unacceptably high rates of false results. Alongside the careful selection of rapid diagnostic tests and the validation of algorithms, strictly observing correct procedures can reduce the risk of false results. In the meantime, to identify false-positive diagnoses at initial testing, patients should be retested upon initiating antiretroviral therapy.

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