by A Bamford, A Turkova, H Lyall et al.
HIV Medicine, (2018), 19, e1-e42
The 2015 Paediatric European Network for Treatment of AIDS (PENTA) guidelines provide practical recommendations on the management of HIV-1 infection in children in Europe and are an update to those published in 2009. Aims of treatment have progressed significantly over the last decade, moving far beyond limitation of short-term morbidity and mortality to optimizing health status for adult life and minimizing the impact of chronic HIV infection on immune system development and health in general. The main updates to the previous guidelines include: an increase in the number of indications for antiretroviral therapy (ART) at all ages; revised guidance on first- and second-line ART recommendations, and additional emphasis on the needs of adolescents as they approach transition to adult services.