Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction

by Polycarp Mogeni, Thomas N Williams, Irene Omedo et al.
The Journal of Infectious Diseases, Vol. 216, Issue 9, 27 November 2017, pp. 1091–1098

8 pp. 1.4 MB
https://academic.oup.com/jid/article-pdf/216/9/1091/22031385/jix321.pdf

Malaria control strategies need to respond to geographical hotspots of transmission. Detection of hotspots depends on the sensitivity of the diagnostic tool used. The authors conducted cross-sectional surveys in 3 sites within Kilifi County, Kenya, that had variable transmission intensities. Rapid diagnostic test (RDT), microscopy, and polymerase chain reaction (PCR) were used to detect asymptomatic parasitemia, and hotspots were detected using the spatial scan statistic. They conclude that malaria control programs may consider PCR testing to guide asymptomatic malaria hotspot detection once the prevalence of infection falls.

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