Efficacy and safety of artesunate-mefloquine therapy for treating uncomplicated Plasmodium falciparum malaria: systematic review and meta-analysis

by Henry Maia Peixoto, Paola Barbosa Marchesini, Maria Regina Fernandes de Oliveira
Transactions of The Royal Society of Tropical Medicine and Hygiene, Vol. 110, Issue 11, Published: 01 February 2017

11 p. 768 kB
https://academic.oup.com/trstmh/article-pdf/110/11/626/10012529/trw077.pdf

Due primarily to the presence of measurement bias in the selected studies, the quality of the evidence was considered predominantly moderate. Statistically significant associations were not observed when artesunate-mefloquine (ASMQ) was compared to other artemisinin-based combination therapies (ACTs). For comparisons with artesunate-amodiaquine and artesunate+sulfadoxine-pyrimethamine, the results were favourable to ASMQ. No deaths were attributed to ASMQ, severe adverse events were rare and some studies indicate a higher frequency of mild adverse events.

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