Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

by Will J. R. Stone, Joseph J. Campo, Matthijs M. Jore
Nature Communicationsvolume 9, Article number: 558 – Published online: 08 February 2018

14 pp. 2.4 MB
https://www.nature.com/articles/s41467-017-02646-2.pdf

Some people develop an immune response following a malaria infection that stops them from infecting other mosquitoes. The antibodies that these people produce are sucked up by the mosquito and destroy the malaria parasite in the mosquito’s stomach. Researchers have discovered that 1 in 25 malaria patients prevent the disease from spreading in this way. They also unravelled the defence proteins responsible, and these could be used to make a vaccine.

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