Clinical Infectious Diseases, Vol. 66, Issue suppl_2, 1 April 2018
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There is an increasing realization that there is a persistent and large burden of human immunodeficiency virus (HIV)–associated morbidity and mortality encountered in countries most affected by HIV. A substantial proportion of patients is still at risk of death due to progressing to advanced HIV – defined by the World Health Organization (WHO) as having a CD4 count <200 cells/µL or WHO clinical stage 3 or 4 disease – and this proportion has remained relatively constant in recent years despite ongoing improvements in access to ART. This supplement brings together a number of articles from a diverse group of authors that highlight the ongoing burden of advanced HIV disease, and opportunities to improve treatment and care for this highly vulnerable patient population.